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Please use this identifier to cite or link to this item: https://nslhd.intersearch.com.au/nslhdjspui/handle/1/31670
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dc.contributor.authorGuo, Lesleyen
dc.contributor.authorKneebone, A.en
dc.contributor.authorEade, Thomas N.en
dc.date.accessioned2021-06-17T07:47:52Z-
dc.date.available2021-06-17T07:47:52Z-
dc.date.issued2013-10-
dc.identifier.citation57(S1):34en
dc.identifier.urihttps://nslhd.intersearch.com.au/nslhdjspui/handle/1/31670-
dc.description.abstractPurpose: To report late radiation toxicity in a contemporary cohort of patients treated exclusively with high dose radiotherapy, daily image guidance and Intensity Modulated Radiation Therapy (IMRT) or Intensity Modulated Arc Therapy (IMAT). Methods and Materials: Patients were followed prospectively using a real time database which included toxicity reported using the modified RTOG scale. The current study included all patients treated between April 2007 and April 2012 with a minimum 12 months follow up. Patients were planned with either 7-9 field IMRT or IMAT. Rectal and bladder planning goals remained unchanged (rectal V65 < 17%, V40 < 35%; bladder V65 < 25% and V40 < 50%). Daily image guidance was used for all patients. Baseline urinary function was assessed with the international prostatic symptom score (IPSS). Late toxicity was estimated using Kaplan Meier statistics. Results: There were a total of 239 patients eligible for analysis with a median age of 72 yrs (46 yrs to 84 yrs). There were 26 diabetic patients (11%). The median IPSS prior to treatment was 6 (0-31). The majority of the patients were either intermediate risk (40%) or high risk (52%). There were 8 patients (3.3%) who had known lymph node metastases. Androgen deprivation was used in 66% of patients (19% short term and 37% long term) and 34% of the patients had pelvic lymph node irradiation with a synchronous boost (56 Gy-60 Gy in 38-40#). Mean delivered dose to the PTV was 79 Gy/38# (n= 102); 81 Gy/39# (n=16) and 83 Gy/40# (n=121). The 3 yr late gastrointestinal and genitourinary cumulative Grade 2+ toxicities were 3.2% and 13.9% respectively. A comparison of the high and low dose cohorts respectively for rectal toxicity (1.8% vs. 4.3%) and bladder toxicity (16.5% vs. 12%) was similar. Conclusion: Doses above 80 Gy can be delivered safely for prostate cancer using daily IGRT combined with IMRT/IMAT.en
dc.languageenen
dc.language.isoenen
dc.relation.ispartofJournal of Medical Imaging and Radiation Oncologyen
dc.titleHigh dose prostate cancer radiotherapy: Late toxicity outcomesen
dc.typeConference presentationen
dc.identifier.affiliationRoyal North Shore Hospitalen
dc.identifier.doi10.1111/1754-9485.12117-
dc.description.pages34en
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/1754-9485.12117en
dc.subject.keywordsMaleen
dc.subject.keywordspatienten
dc.subject.keywordsbladderen
dc.subject.keywordsintensity modulated radiation therapyen
dc.subject.keywordsrisken
dc.subject.keywordsfollow upen
dc.subject.keywordsdata baseen
dc.subject.keywordsHumansen
dc.subject.keywordslow drug doseen
dc.subject.keywordslymph node irradiationen
dc.subject.keywordsRadiotherapyen
dc.subject.keywordspelvis lymph nodeen
dc.subject.keywordslymph node metastasisen
dc.subject.keywordsradiationen
dc.subject.keywordsdiabetic patienten
dc.subject.keywordsstatisticsen
dc.subject.keywordsInternational Prostate Symptom Scoreen
dc.subject.keywordsplanningen
dc.subject.keywordsimage guided Radiotherapyen
dc.subject.keywordsandrogenen
dc.subject.keywordsdrug megadoseprostate canceren
dc.subject.keywordscancer Radiotherapyen
dc.subject.keywordstoxicityen
dc.subject.keywordsNew Zealanden
dc.subject.keywordscollegeen
dc.subject.keywordsradiologisten
dc.relation.conference64th Annual Scientific Meeting of the Royal Australian and New Zealand College of Radiologists, RANZCR 2013. Auckland New Zealanden
dc.subject.ahtRadiotherapyen
dc.subject.ahtProstate Canceren
dc.subject.ahtToxicityen
local.editedby.nameNW 3/12/2021en
dc.relation.departmentNorthern Sydney Cancer Centreen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairetypeConference presentation-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptNorthern Sydney Cancer Centre-
crisitem.author.deptRoyal North Shore Hospital-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptNorthern Sydney Cancer Centre-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptRoyal North Shore Hospital-
crisitem.author.deptNorthern Sydney Cancer Centre-
crisitem.author.deptRoyal North Shore Hospital-
crisitem.author.deptRadiation Oncology-
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